Release of Aspirin from a Polymer Matrix - 2888 Words

Experiment 1: Release of Aspirin from a Polymer Matrix Summary Firstly, aspirin was weigh to 0.25g which was then dissolved in 100cm3 of distilled water by heating to 80 °C using a hotplate. 2.0g of agar was added while stirring and was heated till dispersed, giving almost clear solution. The temperature was control so as not to overheat the agar. The agar was left to cool in an ice bath. Using a hollow cylinder, the agar was cut to approximately 4.0g (the exact weight of the agar was recorded). It was then transferred to a 250cm3 beaker filled with 50cm3 of distilled water and a conductivity probe was placed into the beaker to measure the conductance (Conductivity, Gt, ï  ­S/cm) against time (measured every 1-2 minutes for the interval of 30 minutes). To ensure consistency, the solution was swirl for approximately 10 seconds before the minute was up. Next, the conductance of aqueous solution with only aspirin present was calculated by getting the amount of aspirin through the formula (Y=X/102g aspirin) and it was dissolved into 50cm3 of wat er. The conductance was measured in order to obtain the Control (Ga). From there, the fractions of Aspirin released at any given time (Qt) were measured thus providing the following of the release of the Aspirin by plotting the graph of Log Qt versus Log t. Results t(min) Conductivity, Gt (ï  ­S/cm) Qt Log Qt Log t 1 19.24 0.05830303 -1.234308872 0 2 19.79 0.059969697 -1.222068146 0.301030 3 41.8 0.126666667 -0.897337658 0.477121255 4 52.2Show MoreRelatedDesign Formulation And Evaluation Of Gastroretentive Floating Tablets2194 Words   |  9 Pagesusing HPMC K4M, HPMC K15M and Carbopol 974(p) as polymers. Formulations were prepared by varying the amount of polymers. The compatibility of drug with the polymers is identified by using FTIR studies. Gastric floating of Stavudine tablets results from effervescence produced by the reaction between sodium bicarbonate and hydrochloric acid in stomach. Twelve formulations of floating tablets were prepared using direct compression technique with polymer such as carbopol974 (p), HPMC grades, Xanthum gumRead MoreThe Human Gastrointestinal Track Is A Complex Time9513 Words   |  39 Pages and excretive organ. Key of physiological factors that control absorption of drugs from the GIT include gastric, fluid and food intake, bulk fluid and luminal pH, gastric and intestinal secretions, absorptive mechanisms, enterocyte-based metabolism and secretion. Properties of a drug, su ch as its solubility, stability, ionization, and lipophilicity, strongly influence the rate and extent of drug absorption from GI lumen. Critical assessment of fundamental physicochemical properties and considerationRead MoreA Short Note On Advanced Heart Failure4008 Words   |  17 Pages3411 Biomaterials Wei Shen 5/8/2015 1 Introduction In today’s age of modern medicine and technology, there have been many advances in the treatment of heart disease. These treatment options have the ability to prolong the life of patients suffering from severe cardiac diseases, and in many cases, allow these patients to live a stable lifestyle for many years. Often, the end-stage events of cardiac disease result in advanced heart failure, in which case the best course of action is a heart transplantRead MoreCell Biology Final Essay30093 Words   |  121 PagesName: _Leroy Johnson __________________________________ Date: ______________Comprehensive Study Guide. Test will only be Multiple choice 1. The feature that most clearly separates eukaryotes from prokaryotes is the presence of _______ in eukaryotic cells. A) ribosomes B) oxidative phosphorylation C) DNA molecules -D) a nucleus 2. Cytoplasmic organelles are - A) absent in prokaryotic cells; present in eukaryotic cells. B) present in both prokaryotic and eukaryotic cellsRead MoreDental Question Bank33485 Words   |  134 Pagestooth could see A. B. C. D. E. F. Surface resorption, external resorption Internal resorption Inflammatory resorption Replacement resorption A, C and D All of the above 13. The percentage of total dentine surface dentinal tubules make in 0.5mm away from pulp is A. B. 20% 50% 14. The junction between primary and secondary dentine is A. A reversal line B. Sharp curvature C. A resting line D. A reduction in the number of tubules 3 15. What is the correct sequence of events A. Differentiation of